Alex Rodriguez tied Willie Mays with his 660th home run to go level fourth on the all-time list as the New York Yankees beat their fiercest rivals the Boston Red Sox 3-2 at Fenway Park.
Rodriguez's solo shot over the Green Monster in the eighth proved to be the difference between the sides.
The Oakland Athletics scored seven runs in the eighth inning as they came from 5-0 down to beat the Texas Rangers 7-5.
Mark Canha got the ball rolling with his third home run of the season, before Eric Sogard got home thanks to a Stephen Vogt RBI.
With the bases loaded Josh Reddick singled to centre, with two getting home to make it 5-4 before Brett Lawrie doubled home two runs and Canha singled to centre for 7-5.
Addison Russell registered his first home run for the Chicago Cubs as they beat the Milwaukee Brewers 1-0 while Minnesota pitcher Kyle Gibson allowed just four hits in eight innings as the Twins beat the Chicago White Sox 1-0.
The Houston Astros extended their winning run to nine matches as home runs from Evan Gattis, Jake Marisnick and George Springer saw them to a 4-3 victory over Seattle Mariners.
The struggling Cleveland Indians picked up their second win in a row as Jason Kipnis, Michael Brantley and Brett Hayes all scored home runs in a 9-4 win over the Toronto Blue Jays, while the Tampa Bay Rays beat the Baltimore Orioles 2-0
Matt Harvey became the first New York Mets pitcher to win his first five starts since Pedro Martinez in 2006 in a 4-0 victory over the Washington Nationals, while the Atlanta Braves beat the Cincinnati Reds 4-3.
Chris Young made an impressive debut for the Kansas City Royals as he threw five hitless innings and nine strikeouts in a 4-1 win over the Detroit Tigers.
Marcell Ozuna scored the game-winning double as the Miami Marlins beat the Philadelphia Phillies 4-3, while the St Louis Cardinals beat the Pittsburgh Pirates 2-1 after 10 innings.
Rookie Joc Pederson hit his first career grand slam as the Los Angeles Dodgers crushed the Arizona Cardinals 8-0, pinch-hitter Joe Panik's single in the bottom of the ninth handed the San Francisco Giants a 3-2 win over the Los Angeles Angels and the San Diego Padres were 14-3 winners against the Colorado Rockies.
